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It also supports aerobic metabolism in skeletal muscle and mitochondrial energy production, helping reduce fatigue during and after prolonged efforts

It has become clear that vitamin D deficiency needs to be corrected at multiple levels: (i) vitamin D supplements and/or vitamin D-rich foods need to be consumed to provide adequate vitamin D, (ii) the body needs to be able to upregulate vitamin D-metabolizing genes to convert vitamin D into 25(OH)VD and then to 1,25(OH) 2 VD, and (iii) the levels of inflammatory biomarkers need to be reduced

doi: 10.1016/S0009-9120(87)80090-5

NHS guidance describes an initial phase that can be every other day for 2 weeks (or until symptoms improve).Maintenance schedules are often every 23 months in appropriate long-term cases