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The accumulation of altered key tumor suppressor genes such as TP53 and CDKN2A, which encode p53 and p16INK4A, respectively is associated with the onset, progression and poor prognosis of HPV-negative HNSCC
de Smedt H, Eggermont JA, Wuytack F, Parys JB, Van den Bosch L, Missiaen L et al (1991) Isoform switching of the sarco(endo)plasmic reticulum Ca2 + pump during differentiation of BC3H1 myoblasts
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Instead of blocking specific immune pathways or depleting certain cell populations, tolerogenic strategies attempt to restore the fundamental regulatory mechanisms that prevent autoimmunity in the first place
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