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reduction in heart failure

Tirzepatide can escalate through two receptor pathways

In the TRANSCEND-T2D-1 trial (published in The Lancet , June 2026), individuals with type 2 diabetes lost -15.3% at 12 mg over 40 weeks

However, based on the growing sophistication of 21st Century research approaches [432][433][434][435][436][437][438][439] along with the realization of the consequences of failure [440][441], there is ample support for the optimistic viewpoint that the current selection of orally active treatment options will continue to expand