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Most real-world practice trends toward under-PEEPing, unknowingly leaving the lung on the left limb of the curve, where hidden derecruitment injury accumulates breath by breath

The theory described in the peptide literature is that a GHRH analog (signal one) and a ghrelin-receptor agonist (signal two) act in a complementary, even synergistic, way producing a larger GH pulse together than either pathway alone, because the pituitary carries co-receptors for both inputs

doi: 10.1002/cncr.29229 25 Panobinostat