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Ben Greenfield: And James OKeefe has shown that with some of his research on arterial stiffness and this whole law of diminishing returns or increased mortality with excessive exercise

This well-established importance underlies the role of vitamin B12 deficiency in mood imbalances, psychotic disorders, and neuronal health, particularly in elderly patients, where this deficiency is estimated to affect up to 40% of the population (72)

Some users report losing five times more body fat than average when combined with lifestyle changes

AGEs may also promote vascular dysfunction by reducing the bioavailability of nitric oxide (NO) and inhibiting endothelial NO synthase and antioxidant defense mechanisms 13,14