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4 More recently, the FDA Reauthorization Act of 2017 (FDARA) made a reference encouraging the enrollment of more diverse patient populations, and the Final Rule for Clinical Trials Registration and Results Information Submission (42 CFR Part 11) went into effect in January 2017

Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intake