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CITED4 inhibits hypoxia-activated transcription in cancer cells, and its cytoplasmic location in breast cancer is associated with elevated expression of tumor cell hypoxia-inducible factor 1

Quercetin , the rutin-lysine-generated MRP, effectively inhibits free radicals, enhances activity of antioxidant enzymes (i.e., SOD and CAT), initiates Nrf2-dependent pathway, and upregulates phase II detoxifying antioxidant genes (including NQO1, HO-1, GCLG, and GCLM) 621

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