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Subsecuentemente, la activacin de vas de sealizacin secundarias, incluyendo protena quinasa A (PKA) y Epac2, alteran la actividad de los canales de iones celulares, causando niveles elevados de calcio citoslico que aumentan la exocitosis de grnulos contenedores de insulina

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Autocrine selection of a GLP-1R G-protein biased agonist with potent antidiabetic effects

Fish, Diets and Sampling In order to avoid the metabolic disturbance of estrogen during the sexual maturation of female fish, only male zebrafish (0.25 0.03 g) were bought from Chinese National Zebrafish Resource Center (Wuhan, China)