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8.5.4.1 SMEDDS These systems are isotropic mixtures of oils, surfactants, co-surfactants, and drugs that form fine oil-in-water emulsions or microemulsions upon gentle agitation in aqueous media

Clinical studies have demonstrated exercise-induced increases in autophagy markers in human skeletal muscle, 164 while a randomized controlled trial in MASLD patients showed that intermittent fasting combined with aerobic exercise significantly reduced hepatic steatosis, body weight, and fat mass while improving insulin sensitivity

Patients eating less may also consume different proportions of these foods or may take supplements to compensate for reduced dietary intake

We should not be using obesity pharmacotherapy or surgery in those who do not have the disease of obesity and thus the benefits will outweigh any of those risks if utilized in the indicated patient population.