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The binding affinity of icodec and semaglutide to HSA was investigated by measuring the displacement of icodec and semaglutide from HSA in vitro at increasing concentrations of a soluble fatty acid derivative (SFAD) consisting of a 20-carbon long fatty acid with a 4 -Glu extension, similar to the side chains on icodec and semaglutide

The angle matters: a 90-degree angle works for most, but for people with less subcutaneous tissue, a 45-degree angle is better

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