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4.1 The translational gap between preclinical models and human disease Current insights into the role of ferroptosis in DACD are largely based on evidence from preclinical models, including genetically modified or chemically induced rodents (e.g., db/db mice, STZ-induced rats) and immortalized cell lines (e.g., PC12 cells) ( 4.2 Hurdles in the clinical development of ferroptosis inhibitors Ferroptosis inhibitors, exemplified by Fer-1, have proven effective in preclinical studies

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Serious side effects, such as pancreatitis, gallbladder problems, and low blood sugar, can also occur