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it reflects pharmacokinetics only., Weigh the indication: More conservative avoidance is typically used for elective weight loss, while diabetes management may require individualized planning with obstetric care. Estimated washout timelines (drug clearance, not infant safety) Bottom line breastfeeding and GLP-1 medications While no evidence proves harm, many clinicians currently recommend avoiding GLP-1 medications for weight loss during breastfeeding

Resources FDA: Zepbound (tirzepatide) approval for weight management FDA: Wegovy (semaglutide) cardiovascular benefit approval NEJM: STEP trial Once-Weekly Semaglutide in Adults with Overweight or Obesity NEJM: SURMOUNT-1 trial Tirzepatide Once Weekly for the Treatment of Obesity Nature Medicine: Two-year effects of semaglutide in adults with overweight or obesity (STEP-5 trial) FDA: Risks with compounded semaglutide products FDA: Concerns about unapproved GLP-1 products GLP-1 Weight Loss Program Provider-prescribed semaglutide or tirzepatide as low as $194/mo* Full-dose GLP-1 therapy with ongoing provider support designed for meaningful, sustainable weight loss

100 mg/day for children 1-3 years

While it did not significantly improve the fibrosis stage in this analysis, its efficacy in resolving inflammation is a major step forward