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EASL-EASD-EASO clinical practice guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD)

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[8] [9] Tirzepatide has generated significant clinical interest owing to its dual mechanism of action and the weight-loss outcomes observed in clinical trials

The key safety consideration involves baseline health status: men with active prostate cancer, severe liver disease, or uncontrolled hypertension require individualized risk assessment before starting GLP-1 therapy alongside TRT