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Clinical Studies and Evidence SUSTAIN-6 Trial (Cardiovascular Outcomes) Published in the New England Journal of Medicine (2016), the SUSTAIN-6 trial demonstrated that Semaglutide significantly reduced the risk of major adverse cardiovascular events (MACE) cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke by 26% compared to placebo in patients with Type 2 diabetes and high cardiovascular risk

Insights Into Ongoing Research and Clinical Trials Sublingual semaglutide is still relatively new, so ongoing research and clinical trials are essential to understanding how well it works and how safe it is over time