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Clinical data supporting split-dosing over single daily administration remains limited, but the practice persists in protocols adapted from HIV-associated lipodystrophy treatment where Tesamorelin was originally studied

However, clinical trials have shown that xCT inhibitors are ineffective in patients with glioma and have numerous SASP-related side effects, which highlights the need for further clinical trials in patients with high tumor burdens (90)

Nearly all patients who stick with treatment find burping resolves completely within weeks