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As a result, Nrf2 escapes degradation and translocate to the nucleus, where it binds to Antioxidant Response Elements (AREs) within the promoter regions of target genes

It can also inhibit the activity of sodium ion channels, which play an important role in the transmission of chronic pain signals

if symptoms are present, they are related to GI irritation (anorexia, nausea, vomiting, diaphoresis)

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