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Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors

While there are no extensive RCTs data that discredit the association of irAEs with good clinical outcomes, a landmark analysis of a retrospective review of only 97 patients showed no difference in OS at 3 months in patients on single-agent ICI, even though the incidence of irAEs was associated with an OS (24.3 versus 5.3 months

doi:10.12669/pjms.37.5.3883 [15] Mazaheri T, Sharifi F, Kamali K