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A major player in this process is PC, an anaplerotic enzyme that enables the beta cells to convert half of glucose-derived pyruvate into metabolites that participate in shuttles or cycles that provide intracellular messengers including NADPH, GTP, precursors of short-chain acyl-CoAs, lipids and amino acids which support K ATP -independent insulin secretion that may be equal in importance to ATP production by mitochondria for insulin secretion

GSH depletion dysregulates the spatial control of neutrophil ROS production, converting a targeted defence into indiscriminate inflammatory tissue damage

In contrast, the diagnostic landscape for PCOS is more dynamic, with 12 adopted diagnostics, used in different combinations according to the Rotterdam criteria 2 , and 60 candidates, most of which are based on promising biomarker research