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53 Although dementia was not a primary outcome, a pooled analysis of 15,820 patients with type 2 diabetes randomised to GLP-1 receptor agonist treatment or placebo found a 50% reduction in dementia progression over a median of 3.6 years (15 cases in the placebo group vs 32 in the GLP-1 receptor agonist group)
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No specific contraindications for combination therapies have been established, but prudent clinical practice suggests monitoring for unexpected interactions when initiating novel combination regimens
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