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Topiramate is an anticonvulsant medication originally developed to treat epilepsy and prevent migraines

When excluding patients who had been diagnosed with diabetic retinopathy in the second sensitivity study, use of once-weekly semaglutide was still independently associated with a higher risk to develop NAION (adjusted HR 226, 95% CI 157 327) in a multivariable model adjusted as in the first sensitivity analysis

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All authors read and approved the manuscript