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While the increasing need for novel drugs or drug-release systems has led to vast advancements in nanomedicine, some safety concerns exist (Liu et al., 2020a

Constipation and GI slowdown Delayed gastric emptying is a feature of all GLP-1 agonists, and retatrutide is no exception

Pregnancy is another important contraindication weight-loss medications including GLP-1 RAs are not used in pregnancy (intentional weight loss is not recommended for pregnant women, and animal studies with GLP-1 RAs have shown some fetal growth effects)

In an analysis of data across eight large, multiyear CV outcomes trials for three classes of diabetes agents, researchers also found that participants using insulin at baseline when assigned other diabetes drugs were more likely to experience a major adverse CV event vs