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Besides its effect on oxidative stress, chemotherapy treatment induced neuroinflammation in rat brains

When the torso flexes (bends forward) during sitting, tissue above the scar falls forward, while a tethered or stuck C-section scar acts as a fixed point

The key structural innovation is the side-chain lactam bridge connecting the Asp carboxyl group to the Lys amine, forming a 23-membered macrocycle (Al-Obeidi 1989, PMID 2555512)