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[DOI] [PMC free article] [PubMed] [Google Scholar] 103.Bharucha AE, Charkoudian N, Andrews CN, Camilleri M, Sletten D, Zinsmeister AR, Low PA

Weeks 1-8 (highest risk period): GI side effects are at their peak during initial dose escalation

The injections are quick, simple to administer, and involve minimal pain

More physiologically relevant models such as 3D organoids, patient-derived xenografts, and genetically engineered mice are needed to better predict nanoplatform behavior