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Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity

The olfactory and trigeminal nerve pathways provide a direct nose-to-brain route that bypasses the blood-brain barrier entirely

As a result of this, the PCDS and the Association of British Clinical Diabetologists have updated their joint guidance to assist healthcare professionals to overcome this particular challenge in the management of type 2 diabetes in adults

Is it possible we are missing a treatment effect of Lixisenatide because of the heterogeneity present in most Parkinsons groups recruited for clinical trials (in other words Parkinsons is not one disease and we may have recruited a few different subtypes and this watered down the potential effects)