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Some studies find that obesity is associated with an increase in UCP-2 and UCP-3 mRNA in skeletal muscle (53), others find no association between obesity and UCP-3 mRNA (54), whereas others have described a negative correlation between obesity and skeletal muscle UCP-2 mRNA (55)

In the mitochondrial matrix, SOD2 together with Prx3, GPx, the GSH/GSSG couple and the Trx2/TrxR2 system confines H 2 O 2 and supports controlled redox relays to metabolic enzymes and DNA repair machineries, whereas in the intermembrane space (IMS), SOD1, cytochrome c redox cycling and p66^Shc shape signals that can reach the cytosol

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