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In multiple rodent models of chronic stress (a shared risk factor for major psychiatric illnesses), administration of LAC leads to a rapid and persistent antidepressant-like response by increasing histone acetylation and expression of key genes, including mGlu2 receptors and the downstream brain-derived neurotrophic factor BDNF [27, 30, 34,35,36,37]

[DOI] [PubMed] [Google Scholar] (289).Nakamura A

Oral supplements have to pass through the digestive system and may not be absorbed efficiently, especially in people with gastrointestinal conditions like celiac, Crohns, or gastritis

Efficacy varies by person, and some injectable formulations were previously used for specific indications