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In LPS-induced sepsis, CUL5 interacts with TRAF6 and promotes its K63-linked polyubiquitination at Lys63, leading to the activation of NF-B and MAPK pathways, enhanced expression of inflammatory genes, and subsequent production of pro-inflammatory cytokines such as IL-1, IL-6, and TNF- (122)

Context-Dependent Telomere Effects Recent work included breast-cancer-related cell lines and reported different telomere-maintenance responses between cellular models

"Association between serum gamma-glutamyltransferase and dietary factors: the Coronary Artery Risk Development in Young Adults (CARDIA) Study." American Journal of Clinical Nutrition