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These predispositions do not determine medication efficacy but may help contextualize variation in weight loss response across individuals

Yesvariants in your GLP1R and GIPR genes influence how your body's appetite-control receptors respond to semaglutide, potentially affecting both the dose you need and how sensitive you are to timing changes

Environmental factors such as shift work, irregular eating schedules, artificial light exposure at night, and chronic sleep deprivation can desynchronize central and peripheral clocks, leading to metabolic imbalance (6, 8, 14, 15, 33)

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