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A major extracellular enzyme, GPX3, is also found in the cytoplasm and plasma membranes of the mammalian kidney, epididymis, heart, lung, liver, brain, adipose tissue, mammary gland, and gastrointestinal tract (Nirgude and Choudhary, 2021)

These drugs mimic or enhance the action of endogenous GLP-1 a hormone naturally secreted by intestinal L-cells in response to nutrient intake

Women of childbearing age using GLP-1 therapy should use effective contraception and discuss family planning with their provider

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