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One study in diet-induced obese mice found that an NNMT inhibitor combined with a calorie-restricted diet was associated with shifts in gut bacterial populations, suggesting metabolic intervention can have knock-on effects on gut composition

similarly encapsulated nucleoside-modified mRNA in LNPs for delivery in mice, achieving immediate in vivo expression of hepatocyte growth factor [152]

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The Phase 3 ACHIEVE-2 trial compared oral orforglipron with dapagliflozin in 962 adults with type 2 diabetes taking metformin