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By contrast, megadose, non-targeted antioxidants (blanket vitamins or generic scavengers) typically underperform because they ignore source identity and compartment, pool signals much like bulk Amplex-style readouts and suppress adaptive redox cues essential for resilience and recoveryhence the preference for node- and compartment-aware strategies that are titrated to objective redox biomarkers rather than applied indiscriminately (Le Gal et al