Semaglutide GLP-1 enhances insulin release, particularly when blood sugar levels are elevated, thereby aiding in better glucose control
This gives you enough material to run independent testing while limiting financial exposure
Here, we used the US Department of Veterans Affairs databases to build a cohort of people with diabetes who initiated GLP-1RA ( n = 215,970) and compared them to those who initiated sulfonylureas ( n = 159,465), dipeptidyl peptidase 4 (DPP4) inhibitors ( n = 117,989) or sodiumglucose cotransporter-2 (SGLT2) inhibitors ( n = 258,614), a control group composed of an equal proportion of individuals initiating sulfonylureas, DPP4 inhibitors and SGLT2 inhibitors ( n = 536,068), and a control group of 1,203,097 individuals who continued use of non-GLP-1RA antihyperglycemics (usual care)
The 12mg dose group of retatrutide was significantly better than 1.5mg dulaglutide in reducing blood sugar HbA1c, while the 4mg and above dose groups were significantly better than 1.5mg dulaglutide in reducing body weight
