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Injectable administration bypasses this limitation while topical application provides concentrated local delivery

doi: 10.1038/s41574-021-00507-z 94 PromratKKleinerDENiemeierHMJackvonyEKearnsMWandsJRet al

5a) allows selective inhibition of CBS (raising cellular homocysteine levels and suppressing the production of H 2 S in a dose-dependent manner) over CSE