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The complete supplement protocol for someone on keto plus GLP-1 should include: Electrolytes (sodium, potassium, magnesium) throughout the day Creatine monohydrate: 3 to 5 grams daily Omega-3 fish oil: 2 to 3 grams EPA/DHA combined Vitamin D3: 2,000 to 5,000 IU daily (test levels and adjust) B12: 1,000 mcg methylcobalamin daily Probiotic: multi-strain, 10+ billion CFU Fiber supplement: psyllium husk, 5 to 10 grams daily as needed for bowel regularity Collagen peptides: 10 to 20 grams daily for connective tissue support (also contributes to protein intake) Tirzepatide-specific supplement considerations mirror the general protocol but may require higher electrolyte doses during the initial adaptation period due to the more aggressive appetite suppression and potential for greater fluid shifts