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Aged mice exhibited lower serum testosterone levels compared to young adult mice, confirming age-related hypogonadism

The REWIND and SUSTAIN-6 tests on cardiovascular safety found that both peptides had lower three-point MACE scores than the placebo

Request referral to appropriate specialists if needed Liver assessment : Ensure proper diagnosis through blood tests, FIB-4 calculation, and if indicated, imaging (ultrasound or FibroScan) or ELF testing Specialist review : Hepatology or endocrinology input may be needed to assess suitability Clinical trials : Some patients may be eligible for research studies examining GLP-1 agonists in NAFLD/NASH Patients should be aware that even when prescribed, GLP-1 agonists require ongoing monitoring, lifestyle modification remains essential, and treatment should be reviewed regularly to assess response and tolerability

Body composition changes with retatrutide saw significant decreases in both total and visceral fat while retaining lean muscle mass