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Some people report mild discomfort when they first introduce this powerful molecule into their routine

The STEP 5 trial analyzed the efficacy and safety of once weekly semaglutide 2.4 mg in comparison to placebo (alongside lifestyle changes) for long-term treatment of adults with obesity, or overweight with at least one weight-related health condition, without diabetes

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Nevertheless, there is no doubt that GLP-1 interacts with vagal afferent neurons and the arcuate nucleus of the hypothalamus, critical components of the gut-brain axis that connect peripheral metabolic signals to the central nervous system [10]