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Comparative in silico analysis of butyrate production pathways in gut commensals and pathogens

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The declining plasma concentration provides a quantitative framework for researchers designing dose-response studies, as physiologically relevant in vitro concentrations should bracket the 200-500 nM range to model the young-to-aged spectrum

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The disorder usually presents in early childhood and is characterized by episodes of hypoketotic hypoglycemia (that can cause encephalopathy), hepatomegaly, elevated liver enzymes (transaminases), and hypoammonemia in infants

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