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Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD

The literature also describes upregulation of growth factors involved in tissue repair, modulation of nitric oxide synthase activity, and effects on the dopaminergic and serotonergic systems that are harder to interpret clinically [Sikiric et al., Inflammopharmacology, 2018]

Based on what weve learned so far, we believe the following is the most accurate definition of Peyronies Disease