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Disease-modifying therapies for underlying MS

This is a calculator example, not a personal dosing recommendation

The cut-off point ranges from 3 to 5.1 g/L when hypoglycemia is 30 kg/m2) and over-weight (BMI 25 to 30 kg/m2) patients with a low pretest probability, we recommend a lower cutoff of 1 g/L to avoid false-positive diagnosis, because obesity physiologically reduces GH responses to stimulation tests (44)

As a basic characteristic of diabetes, hyperglycemia function as the initiating injury factor of BBB leakage, and other injury factors induced by hyperglycemia further aggravate the damage of BBB, such as advanced glycation end-products, inflammation, oxidative stress, metalloproteinase, astrocyte apoptosis, microglia polarization to swallow astrocytic end-feet, nerve/glial antigen 2 (NG2-glia) proliferation, pericyte death, and lower endothelial tight junction coverage