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WD consumption in middle-age, increased inflammation in the amygdala of females, and in the ventral hippocampus of males, whereas GE2 treatment reduced inflammation in the hippocampus and amygdala, depending on diet and sex

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During mucosal inflammation, inflammatory cytokines activate NADPH oxidase (NOX) and inducible nitric oxide synthase (iNOS), leading to the release of superoxide from intestinal epithelial cells, neutrophils, and macrophages [18]