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demonstrated that topical GHK-Cu at concentrations as low as 0.01% stimulated collagen synthesis in human dermal fibroblast cultures, and clinical application of GHK-Cu-containing creams improved skin thickness and elasticity in photoaged skin over 12 weeks [1]

Under review simply means the FDA is still assessing: Safety Clinical relevance Regulatory appropriateness It does not mean: The peptide is approved The peptide is widely available The peptide is appropriate for general use At this stage, access to many of these substances may remain limited, inconsistent, or restricted, and quality can vary outside regulated pathways

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[PubMed: 6893334] 266