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While full restoration to youthful levels isnt guaranteed and NAD+ therapy research in humans is still a bit limited, there are studies that support its superiority over diet and exercise alone in significantly raising NAD+ concentrations and promoting healthier aging, especially after 40 when natural production declines sharply

The distinction matters because vasodilation is temporary, requiring continuous application to maintain

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Baseline Metabolic Status: Are your research subjects metabolically healthy, or are they models of obesity, insulin resistance, or diabetes