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Monitoring biofilm activity through tools like biofilm thickness sensors or regular measurement of BDOC (biodegradable dissolved organic carbon) can help operators ensure that the biofilm is functioning properly

A 2024 metabolism study added another layer of complexity

Use ketoconazole tablets with caution in patients with cardiac disease or other conditions that may increase the risk of QT prolongation including cardiac arrhythmias, congenital long QT syndrome, heart failure, bradycardia, myocardial infarction, hypertension, coronary artery disease, hypomagnesemia, hypokalemia, hypocalcemia, or in patients receiving medications known to prolong the QT interval or cause electrolyte imbalances