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In a 1997 research paper, the authors observed that the peptide may be used to decrease the size of tumors in cases of ovarian, uterine, and cervical cancer while acting to restore cellular immunity [14]

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These substitutions protect against dipeptidyl peptidase-IV (DPP-IV) cleavage, the enzyme that destroys natural GHRH within minutes (Alba et al., J Med Chem 2006)