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Modification of histones can affect the exposure of the DNA nucleotide sequence and thus affect the transcription level of the gene

[7] So the honest one-line summary is that both build on GLP-1 but recruit a different second pathway amylin for CagriSema, GIP for tirzepatide and there is a further structural difference underneath that: CagriSema achieves its dual action with two separate peptides, while tirzepatide achieves its dual action with one

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