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For LL-plSAM-FVpE group and LL-plSAM group, BALB/c mice were immunized orally with LL-plSAM-FVpE or LL-plSAM (3 10 9 CFU) respectively on days 1, 2, 8, 9, 15, 16, 22 and 23

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Pharmacological options with established evidence include acamprosate, naltrexone, and disulfiram for maintaining abstinence

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