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Some evidence suggests that in AD, dysregulation of tight junction proteins, increased matrix metalloproteinase signaling, and degeneration and loss of pericytes may all contribute to BBB leakage, leading to the accumulation of numerous blood-derived neurotoxic proteins in the brain, causing neuroinflammation and oxidative stress

Particularly, defects in glucose metabolism and mitochondrial dysfunction limit the availability of ATP to CNS tissues and muscle

"Studies show" gets thrown around a lot in this category without anyone naming the studies

Interventions All patients received 100 mg of sertraline (Tehran-Daru Pharmaceutical Company, Iran) daily along with either 1000 mg carnitine (Vana-Darougostar Pharmaceutical Company, Iran) or placebo (cooking starch), prepared in identical capsules