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Description

PPP did not compete with ATP but interfered with phosphorylation in the activation loop of the kinase domain, in which it specifically blocked phosphorylation of the tyrosine (Y) 1136 residue, while sparing the two others (Y1131 and Y1135)

P.CepanecC.ScholteJ.SaudubrayJ

520 Imvax is conducting a randomized, multicenter, double-blind, placebo-controlled Phase IIb study (NCT04485949) to evaluate IGV-001 in patients with newly diagnosed GBM