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Davis, B

Within cells (principally the liver where it is stored) the folic acid found in enriched food and in vitamin supplements is converted first to dihydrofolate (DHF) and then to tetrahydrofolate (THF also H 4 folate) through the action of dihydrofolate reductase, an NADPH-requiring enzyme

This suggests that when natural products are used as adjuvant therapy for sepsis, their interactions with antibiotics should be systematically evaluated to ensure the safety and efficacy of combination therapy