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limited clinical data Management: Monitor thyroid function if symptoms of hypothyroidism develop Chemotherapy Agents: Conflicting evidence on interaction with chemotherapy Concern: Taxanes (paclitaxel, docetaxel): Some evidence suggests ALC may worsen CIPN when used during chemotherapy may consider after completion of treatment for established neuropathy Recommendation: Avoid ALC during active chemotherapy

The longest clinical trials extended to 24 weeks (approximately six months) of continuous AOD-9604 administration

The Hatch-Waxman Amendments permit a patent restoration term of up to five years as compensation for patent term lost during product development and the FDA regulatory review process

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